The design of the pharmaceutical process equipments should be suitable for its intended use, the cleaning and the maintenance of the equipment. The materials used in the construction of the equipment that comes in to contact with the drug product and its components must be compatible with the drug manufacturing process, the cleaning and sanitation processes. Cleaning, sanitization and sterilization must be required for these equipments. Cleaning means removal of containment residues from product contact surfaces of equipment. Containment residues include residuals from drug products, residues from cleaning agents or other general types of contamination like grease, oil and dirt. Sterilization and sanitization deal with the removal of microorganisms from the product contact surfaces of the equipment. The difference between sterilization and sanitization is that sterilization refers to total elimination of all living organism while sanitization refers to a reduction in the number of living organism.