Thermophilic Bioreactors are operated at thermophilic temperature of 50 to 58°C. The organism thermophilia plays a key role in thermophilic bioreactors. This reactor is used to study the treatment of pig manure. These bioreactors support mixed consortia of microorganisms that can simultaneously convert a broad spectrum of compounds into new cells, innocuous byproducts, carbon dioxide and water. These reactors are less adept at simultaneously utilizing multiple substrates and in achieving efficient removal of carbonaceous substances. In the thermophilic reactors, several phylotypes are detected that clustered with obligate anaerobes. They are used to treat pharmaceutical wastewater that refers to the presence of clones in bioreactors.